Broad Spectrum Antibiotics known as Fluoroquinolones Could Cause Aortic Dissection or Aortic Aneurysm
Fluoroquinolones are a class of antibiotic which includes Levaquin, Cipro and Avelox. i Approximately 23 million people receive a prescription for fluoroquinolones each yearii, and fluoroquinolones are broad spectrum antibiotics typically used to treating respiratory and urinary tract infections. iii In July 2016, the Food & Drug Administration approved safety label changes to enhance warnings about disabling and potentially permanent side effects as well as to limit the use of fluoroquinolones. iv
Fluoroquinolones, such as Levaquin, Cipro and Avelox, have been associated with severe complications caused by collagen degradation. This means that fluoroquinolones are associated with degrading the main structural protein in connective tissue. Medical literature proves that fluoroquinolones are associated with collagen degradation complications such as permanent peripheral neuropathy. v For years, Robins Cloud has been a leader in the fluoroquinolone lawsuits helping individuals hold fluoroquinolone manufacturers responsible for permanent peripheral neuropathies. vi
Fluoroquinolones and Risk of Aortic Dissection and Aortic Aneurysm
Robins Cloud is also helping individuals suffering from aortic dissection or aortic aneurysm after taking a fluoroquinolone.
Recently, JAMA Internal Medicine published "Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone." vii The authors of this paper explained that this study was to determine if fluoroquinolones’ association with collagen degradation also meant that fluoroquinolones were associated with an increased risk for aortic aneurysm or dissection. This November 2015 publication proved that fluoroquinolones also placed individuals at an increased risk for aortic aneurysm or dissection. More specifically, the authors noted
"After propensity score adjustment, current use of fluoroquinolones was found to be associated with increased risk for aortic aneurysm or dissection (rate ratio [RR], 2.43; 95% CI, 1.83-3.22), as was past use, although this risk was attenuated (RR, 1.48; 95% CI, 1.18-1.86)," the authors of the study wrote. "Sensitivity analysis focusing on aortic aneurysm and dissection requiring surgery also demonstrated an increased risk associated with current fluoroquinolone use, but the increase was not statistically significant (propensity score–adjusted RR, 2.15; 95% CI, 0.97-4.60)."
The authors concluded that these events may be rare, but physicians should be aware of this possible drug safety risk associated with fluoroquinolone therapy."
Around this same time, the British Medical Journal published their study of fluoroquinolones. The authors wrote that "[s]evere collagen-associated adverse events were more common during fluoroquinolone treatment than control periods, including ... aortic aneurysms (0.35 vs 0.13/100-person-years, p<0.001)." viii The British Medical Journal authors concluded, like the JAMA Internal Medicine authors, that fluoroquinolones may contribute to aortic aneurysm.
What is Aortic Dissection?
An aortic dissection is a tear in the wall of the major artery carrying blood away from the heart. ix The tear can result in blood flowing between the layers of the blood vessel wall. Signs or symptoms of an aortic dissection, which may appear like a heart attack, include:
Patients suffering from aortic dissection typically need emergent medical care. Without proper medical treatment, an aortic dissection can cause:
What is Aortic Aneurysm?
An aortic aneurysm is a bulge or "ballooning" of the blood vessel carrying blood away from the heart. x Depending on the size of the aneurysm, it can rupture, causing
Our Fluoroquinolone Lawsuit
In 2015, we were honored to have been among the top one percent of lawyers nationwide to be selected for the prestigious 2015 Litigator Awards. This recognition came in part from our work on behalf of patients involved in a fluoroquinolone lawsuit.
The lawsuit claims that the manufacturers of fluoroquinolone drugs used labels that were purposefully worded to trick patients into thinking the drugs were safer than they actually were.
Unfortunately, fluoroquinolones, such as Levaquin, Cipro and Avelox, have been linked to dangerous side effects. If you or a loved one has suffered as a result of fluoroquinolone, you should discuss your case with Robins Cloud attorneys as soon as possible. Contact us by completing our online form or call us at 866-517-9520 for a free case consultation by our fluoroquinolone attorneys.
Fill out the form below or call us at 866.517.9520 for a free consultation about your Fluoroquinolones case.